Dual Nasal and Pulmonary Targeting to Optimize Mucosal Absorption: Exploring Methods, Devices and Formulations
Lastow O, Viklund M, Karlsson S, Akerberg V, Ekstrom M.
Respiratory Drug Delivery 2023. Volume , 2023: 27-34.
Abstract:
Dual nasal and pulmonary targeting offers the potential to maximize mucosal absorption in the respiratory tract which may result in more efficacious vaccines and treatments against respiratory viruses. Tests of commercially available dry powder inhaler (DPI) products suggest that it is feasible to simultaneously deliver drug to the nasal cavity, to the oropharyngeal region and to the lung. An effective deggregation mechanism, capable of producing an aerosol optimized for pulmonary delivery, is most likely the best strategy for combined nasal and pulmonary dry powder delivery.
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