Combining Modeling with Advanced Experimental Techniques to Optimize Formulation and Nozzle Design for Low GWP pMDIs
Duke DJ, Nguyen DT, Scott HN, Kusangaya AJ, Kastengren AL, Schmidt D, Honnery D.
Respiratory Drug Delivery 2021. Volume , 2021: 35-44.
Abstract:
The design of the next generation of pressured metered dose inhalers (pMDIs) will be driven by the transition to low global warming potential (GWP) propellants. One of the major design challenges is the optimization of the actuator nozzle to achieve equivalent or improved outcomes to current generation devices. Thermophysical property changes and a myriad of fluid-mechanical effects complicate the link between formulation and nozzle design. In this paper, using model solution formulations of hydrofluoroalkane 134a (HFA-134a) and HFA-152a propellants, state-of- the-art X-ray and optical diagnostic tools for pMDI sprays are combined with advanced computer modeling to identify and test new nozzle designs that can be optimized for use with low GWP propellants.
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