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Improving Pulmonary Drug Delivery in Capsule Inhaler Systems: Optimizing Capsules Based on Formulation-Capsule-Device Interactions

Stegemann S, Cadé D, Tardy C.

RDD Asia 2014. Volume , 2014: 25-32.

Abstract:

Capsule-based dry powder inhalation (DPI) systems have gained significant interest for the provision of respiratory drug therapy, especially in emerging economies due to their cost effectiveness and ease of manufacture. Capsule-based DPI systems comprise three important interacting components, the formulation: the capsule or container, and the device. The performance of the DPI system, with respect to product stability, powder release, as well as powder dispersion, is influenced by the capsule material, the inner capsule surface properties and the piercing or shearing behavior. Gelatin and hydroxypropylmethylcellulose (HPMC) capsules both meet the regulatory requirements for inhalation products but exhibit different physical and chemical attributes including moisture content, potential for static charging, piercing, and cutting performance. Capsules can be customized with respect to moisture level and inner lubrication in conjunction with a specific formulation and device. This article will provide scientific insight into the characteristics, optimization process, and selection of capsules to achieve the targeted product characteristics and performance criteria.